Adjuvant Therapy of Primary Breast Cancer VI by E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn,

By E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn, Richard D. Gelber Ph.D, Prof. Dr. med. Aron Goldhirsch, Priv.-Doz. Dr. med. Beat Thürlimann (eds.)

This quantity presents an up to date survey of present laboratory and, normally, medical study at the diagnostic and treatments in basic breast melanoma. The chapters derive from the invited professional lectures provided on the sixth foreign convention on fundamental Breast melanoma held in St. Gallen, Switzerland, in February 1998. the global breast melanoma group has been eagerly expecting this quantity and its consensus platform and proposals. there's no substitute to this assembly and booklet within the box of adjuvant treatment of basic breast cancer.

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0 "~ .. oo o • •• ......... 0. 0 ~ 30 • • ct........ · o • 0 . • • ...... tJ .. ce~ 0 . " \.... o O~ , 0 0 _ .... ~. 4-HPR _ _~______~______~____~oCTR 40 50 60 70 Age Fig. 2. Effect of fenretinide (4-HPR) as a function of age on plasma IGF-I concentrations measured after 1 year of treatment. Levels of IGF-I are adjusted for baseline values. control group aR New Compounds Together with tamoxifen and fenretinide, there is a long list of chemoprevention agents that may be used in breast cancer prevention.

1997). Consistent areas of LOH in these lesions indicate the possible presence of genes involved in the earliest stages of breast cancer development. Advantages of LOH assessment are increased resolution (compared with CGH) and speed. The limitation of LOH is the availability of suitable markers and the dependence on large amounts of DNA; from microdissected lesions only a few markers (4-6) can be studied, making a genome-w,ide search in individual lesions impossible. More recently, the application of DOP-PCR technique to LOH analysis has been shown to generate sufficient DNA for using more markers without loss of accuracy (Chen et al.

A mutation analysis by sequencing is a labour-intensive process and very expensive (currently over US$2000 for BRCAI and BRCA2). Rapid and cheaper throughput assays are being developed using microarray technology. The molecular genetic profile of the tumour has prognostic value, but more importantly it can be used to predict tumour behaviour and response to therapy. Thus, cancers with p53 gene mutation have been shown to have a worse prognosis and are resistant to DNA-damaging chemotherapeutic agents.

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