Advances in Nutrition and Cancer by Elio Riboli (auth.), Vincenzo Zappia, Salvatore Panico, Gian

By Elio Riboli (auth.), Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione (eds.)

This ebook includes complaints from the 3rd foreign convention on Advances in food and melanoma, held in Naples in could 2012. This hugely multidisciplinary assembly analyzed “nutrition and melanoma” from varied views and at the foundation of precise and up to date experimental ways. wisdom at the relation among way of life, vitamin, and melanoma is explored in a couple of contributions, and the function of nutritional intervention in melanoma sufferers is mentioned. problems with important curiosity to the learn neighborhood, similar to epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of motion of normal compounds within the diet), obtain distinct attention. yet another key subject is the rising molecular applied sciences (the “omics”) that may solid gentle at the interaction among foodstuff and human malignancies. Chapters take the shape of stories that come with sections offering professional opinions.

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Another important cancer-related inflammatory mediator is cyclooxygenase (COX)-2, an enzyme that is upregulated in most tumors and catalyzes the synthesis of the potent inflammatory lipid metabolite, prostaglandin E2. COX-2 overexpression is an indicator of poor prognosis in multiple cancer types [48]. In some cancers, inflammatory conditions precede malignant changes (as previously mentioned), whereas, in other cancer types, genetic alterations and premalignant changes precede the inflammatory microenvironment and neoplasia [44].

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