By John T. Lett
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Extra resources for Relative radiation sensitivities of human organ systems / 2
C. Giant Cells and Growth Alterations Puck and Marcus (1956) reported in their initial irradiation study of the HeLa cell that various types of evidence of mitotic death of cells were observed, including failure of mitosis, delayed division, and decreased colony sizes. They also found that a cell could divide a few times and then undergo delayed death, abnormal mitosis, or giant-cell formation. One type of mitotic aberration observed was an amitotic nuclear division in the absence of cytokinesis.
Sublethal Damage and Low-Dose-Rate Radiobiology Concepts of SLDR are based on the shoulder region and the multitarget nature of the survival curve, and can be shown by the two-dose frac tion or split-dose method. Repair of SLD is not noted with exponential (no shoulder) survival curves—for example, with high-LET radiation such as neutrons—when done in vivo (Hornsey and Silini, 1962). A sepa rate way of showing SLDR depends on the use of LDR irradiation (Bed ford and Hall, 1963; Bedford and Mitchell, 1973, 1977).
Jones et al. , 1976), as was the case for Henrietta Lacks. The first human cancer cell line established in tissue culture was the HeLa line. It continues as the most prolific, widely studied, hardiest, and most widely cultured human cancer cell known to date (Broad, 1980). Already widely commented on in the journal Science, HeLa characteris tics were noted to be present not only in the HeLa line but also in 66 other cell lines designated to be of other origins (Hsu, 1976). , 1980), Chang liver, amnion cells, and other cell lines (Table I).