By Randall Lee MD PhD
This factor of Interventional Cardiology Clinics examines techniques to left atrial appendage exclusion. subject matters comprise stroke and bleeding dangers in sufferers with atrial traumatic inflammation, embryology and anatomy, purpose, catheter-based endocardial closure, pericardial entry, catheter-based epicardial closure, surgical closure, machine and left atrial appendage particular attribute for winning closure, medical effects, the function of CTA and MRA imaging, imaging with TEE, post-procedural administration, and prevention and administration of complications.
"…An first-class booklet, written by means of specialists within the field...I may hugely suggest it to scientific and surgical employees attracted to this subject." Reviewed by Perfusion, Apr 2015
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Extra info for Approaches to Left Atrial Appendage Exclusion, An Issue of Interventional Cardiology Clinics
In one prior study, the cumulative incidences of major bleeding at 1, 12, and 48 months were 3%, 11%, and 22%, respectively. 3% per month after the first year of therapy. Five independent risk factors for major bleeding—age 65 years or greater, history of stroke, history of GI bleeding, a serious comorbid condition (recent myocardial infarction, renal insufficiency, or severe anemia), AF—predicted major bleeding. 23 Untreated and out-of-target-range patients Many patients never receive oral anticoagulant therapy, and many of those who are treated are often out of therapeutic range.
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Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Followup Investigation of Rhythm Management (AFFIRM) study. Am Heart J 2005;149(4):650–6. Dewilde WJ, Oirbans T, Verheugt FW, et al, WOEST Study Investigators. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet 2013;381(9872):1107–15.