Basis and Treatment of Cardiac Arrhythmias by M.J. Janse, M.R. Rosen (auth.)

By M.J. Janse, M.R. Rosen (auth.)

This ebook contains the main up-to date info concerning mechanisms and remedy of cardiac arrhythmia. the various subject matters mentioned during this textual content mirror very lately undertaken learn instructions together with genetics of arrhythmias, cellphone signalling molecules as capability healing ambitions and trafficking to the membrane. those new techniques and implementations of anti-arrhythmic treatment derive from many a long time of study as defined within the first bankruptcy by way of exclusive Professors Michael Rosen (Columbia collage) and Michiel Janse (University of Amsterdam). The textual content covers alterations in techniques to remedy over the years, arrhythmias in a number of cardiac areas and over many scales, from gene to protein to cellphone to tissue to organ.

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As already mentioned, Lewis later changed his mind and supported re-entry as the mechanism (Lewis 1920). The circus movement theory held the field for a long time until Scherf in 1947 revived the theory of the rapidly firing focus. He applied aconitine focally to the atrium and in this way could cause atrial fibrillation. Later experiments by Moe and Abildskov (1959) showed that, after application of aconitine to the atrial appendage, clamping off the appendage resulted in restoration of sinus rhythm, whereas the clamped-off appendage exhibited a rapid, regular tachycardia.

The 42 I. S. Cohen · R. B. Robinson so-called pacemaker current, I f , generated by the HCN gene family, best fits these criteria. The biophysical and molecular characteristics of this current are reviewed, and progress to date in developing selective pharmacologic agents targeting I f and in using gene and cell-based therapies to modulate the current are reviewed. Keywords Sino-atrial node · Automaticity · Pacemaker · HCN · Arrhythmia · Pharmacologic selectivity 1 Introduction The sino-atrial (SA) node is the specialized region of the cardiac right atrium where the heartbeat originates.

Shaw and Sons, London 36 M. J. Janse · M. R. Rosen Lewis T (1925) The mechanism and graphic registration of the heart beat, third edn. Shaw and Sons, London Lewis T, Schleiter HG (1912) The relation of regular tachycardias of auricular origin to auricular fibrillation. Heart 3:173–193 Lewis T, Feil S, Stroud WD (1920) Observations upon flutter and fibrillation. II. The nature of auricular flutter. Heart 7:191–346 Ling G, Gerard RW (1949) The normal membrane potential. J Cell Comp Physiol 34:383–396 Loh P, Ho SY, Kawara T, et al (2003) Reentrant circuits in the canine atrioventricular node during atrial and ventricular echoes.

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