Beneficial Effects of Fish Oil on Human Brain by Akhlaq A. Farooqui

By Akhlaq A. Farooqui

It is changing into more and more obvious that the deficiency of n-3 fatty acids in nutrition is not just linked to cardiovascular illnesses, but additionally fascinated about stroke, epilepsy and different neurological and neurodegenerative illnesses, reminiscent of Alzheimer ailment, Parkinson illness, and peroxisomal ailments. In his most up-to-date publication, Beneficial results of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands at the prestige and healing significance of n-3 fatty acids (major elements of fish oil) and their mediators in general mind and people with neurodegenerative and neuropsychiatric illnesses. Farooqui provides the advantages of n-3 fatty acids on Western nutrition, that's enriched in n-6 fatty acids (major elements of vegetable oil) and will advertise the above neurological issues. The booklet will current readers with innovative and accomplished info on metabolism and roles of neural membrane n-3 fatty acids.

Neuroscientists, clinicians, neurologists, neuropathologists, opthamologists, dietitians, and nutritionists will locate this e-book invaluable for realizing the molecular foundation of n-3 fatty acids and their lipid mediators (resolvins and neuroprotectins) in neuroprotection in acute neural trauma (stroke, spinal wire trauma and head harm) and neurodegenerative diseases.

About the Author:

Dr. Akhlaq A. Farooqui is a pace-setter within the box of mind phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, and glutamate-induced neurotoxicity. He has came across the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) and diacyl- and monoacylglycerol lipases in brains from sufferers with Alzheimer ailment. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and raises degrees of eicosanoids which may be regarding the lack of synapses in brains of sufferers with Alzheimer sickness. Dr. Farooqui has released leading edge study at the new release and id of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity by means of lipidomics. He has formerly authored 4 monographs: Glycerophospholipids in mind: Phospholipase A2 in Neurological Disorders (2007); Neurochemical facets of Excitotoxicity (2008); Metabolism and services of Bioactive Ether Lipids in Brain (2008); and Hot themes in Neural Membrane Lipidology (2009). All monographs are released via Springer.

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The expression of GAP-43 is significantly increased in neurons co-cultured with astrocytes in the presence of albumin. Detailed investigations on this topic have indicated that astrocytes internalize albumin in vesicle-like structures by receptor-mediated endocytosis. , 2002). It is proposed that during brain development, oleic acid synthesis is the feedback mechanism regulated by the sterol regulatory element binding protein-1. This protein mediates the transcription of stearoyl-CoA 9-desaturase, the key rate-limiting enzyme for oleic acid synthesis.

2005). Collectively, these studies suggest that EPA and DHA differ on their effects on plasma lipid profiles, gene expression, and neural membrane structure. 4 Effect of n–3 Fatty Acids on Receptors The dietary depletion of DHA stimulates caspases and downregulates NMDA receptors in Tg2576 mouse brain. , 2005). , 2005). , 1999). , 2006). , 1999). Collective evidence suggests that n–3 fatty acids have many beneficial effects on brain tissue through their action on neural membrane structure and serving as precursors for potent lipid mediators.

The expression of GAP-43 is significantly increased in neurons co-cultured with astrocytes in the presence of albumin. Detailed investigations on this topic have indicated that astrocytes internalize albumin in vesicle-like structures by receptor-mediated endocytosis. , 2002). It is proposed that during brain development, oleic acid synthesis is the feedback mechanism regulated by the sterol regulatory element binding protein-1. This protein mediates the transcription of stearoyl-CoA 9-desaturase, the key rate-limiting enzyme for oleic acid synthesis.

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