Biological reaction engineering: dynamic modelling by Irving J. Dunn, Elmar Heinzle, John Ingham, Jiri E. Prenosil

By Irving J. Dunn, Elmar Heinzle, John Ingham, Jiri E. Prenosil

During this ebook, the modelling of dynamic organic engineering methods is gifted in a hugely comprehensible method utilizing the original blend of simplified basic thought and direct hands-on desktop simulation. the math is saved to a minimal, and but the 60 examples provided on a CD-ROM illustrate virtually each point of organic engineering technological know-how. each one instance is defined intimately, together with the version equations. The programms are written within the sleek effortless simulation language Berkeley Madonna, that are run on either home windows notebook and Power-Macintosh computers.

Madonna solves versions comprising many traditional differential equations utilizing extremely simple programming, together with arrays. it's so robust that the version parameters can be outlined as "sliders", which permit the influence in their switch at the version habit to be obvious presently. info should be incorporated for curve becoming, and sensitivity or a number of runs could be played. the implications might be obvious at the same time on multiple-graph home windows or through the use of overlays. The examples might be assorted to slot any actual scenario, and the instructed workouts supply sensible guidance.

The large event of the authors, either in collage educating and foreign classes, is mirrored during this well-balanced presentation, that's compatible for the trainer, the scholar, the biochemist or the engineer.

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Extra resources for Biological reaction engineering: dynamic modelling fundamentals with simulation examples

Example text

This is often done by difference, having measured the mol fraction of oxygen and carbon dioxide concentration in the exit gas. 5 Stoichiometry, Elemental Balancing and the Yield Coefficient Concept Stoichiometry is the basis for any quantitative treatment of chemical and biochemical reactions. In biochemical processes it is a necessary basis for building kinetic models. 1 Simple Stoichiometry The Stoichiometry of chemical reactions is used to relate the relative quantities of the different materials which react with one another and also the relative quantities of product that are formed.

Also fast equilibrium reactions or conformational changes of proteins having time constants below milliseconds should be ignored. Fast reactions can, however, be very important when considering allosteric activation or deactivation of proteins or simply pH-changes during biochemical reactions. 3 Formulation of Balance Equations 47 pH changes can have dramatic effects on the enzyme and microbial activity but can also strongly influence absorption and desorption of carbon dioxide. g. a protein balance.

Glucose + 12 NADP+ + ATP + 7 H2O -> 6 CO2 + 12 (NADPH + H+) + + ADP + Pi where 1 mol of glucose reacted, consumes 7 mol of water and produces 6 mol of carbon dioxide. Here the molar quantities of NADPH and ATP produced and consumed, respectively, are shown. For many complex biological reactions, however, not all the elementary reactions and their contributions to the overall observed reaction stoichiometry are known (Roels, 1983; Bailey and Ollis, 1986; Moser, 1988). Thus the case of a general fermentation is usually approximated by an overall reaction equation, where Substrate + Nitrogen source + O2 -> Product + CO2 + H2O v N H3(t)NH 3 + v02(t)O2 > VC02(t) CO2 + VH2o(0 H2O where the i-th product, such as metabolites or biomass, is given by a general formula.

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