By Sarah S. Long MD, Larry K. Pickering MD, Charles G. Prober MD
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Additional info for Principles and Practice of Pediatric Infectious Disease Revised Reprint, Third Edition
Consider the study design • Type of study • Selection of study participants • Selection and deﬁnition of outcome variables • Selection and deﬁnition of exposure (predictor) variables • Sample size and power 3. Consider the analysis • Complete accounting of study subjects and outcomes • Appropriateness of statistical tests • Potential sources and impact of bias • Potential impact of confounding and effect modiﬁcation 4. Consider the interpretation of results • Magnitude and importance of associations • Study limitations • Ability to make causal inferences CHAPTER CHAPTER 2 Pediatric Infection Prevention and Control Jane D.
MMWR 2006;55:RR-2 Guideline for disinfection and sterilization in health-care facilities (in revision) Guideline for prevention of healthcare-associated pneumonia, 2003. MMWR 2004;53(RR-3) Guideline for environmental infection control in health-care facilities, 2003. MMWR 2003;52(RR-10) Guideline for hand hygiene in health-care settings, 2002. MMWR 2002;51(RR-16) Guideline for prevention of intravascular catheter-related infections, 2002. MMWR 2002;51(RR-10) Recommendations for preventing transmission of infections among chronic hemodialysis patients, 2001.
15 There are theoretical concerns that infection risk will also increase in association with the innovative practices of co-bedding and CHAPTER 2 11 kangaroo care in the NICU because of increased opportunity for skinto-skin exposure of multiple-gestation infants to each other and to their mothers, respectively. 16 Finally, exposure to vancomycin and to thirdgeneration cephalosporins contributes substantially to the increase in infections caused by vancomycin-resistant enterococcus (VRE) and multidrug-resistant gram-negative bacilli, including extendedspectrum beta-lactamase (ESBL)-producing organisms, respectively.