The Cell Cycle in the Central Nervous System (Contemporary by Damir Janigro

By Damir Janigro

Phone Cycle within the principal frightened approach overviews the adjustments in mobilephone cycle as they relate to prenatal and put up natal mind improvement, development to neurological affliction or tumor formation.Topics coated variety from the cellphone cycle throughout the prenatal improvement of the mammalian imperative fearful process to destiny instructions in postnatal neurogenesis via gene move, electric stimulation, and stem cellphone advent. extra chapters learn the postnatal improvement of neurons and glia, the rules of mobilephone cycle in glia, and the way that legislation may perhaps fail in pretumor stipulations or following a nonneoplastic CNS reaction to harm. Highlights comprise remedies of the results of deep mind stimulation on mind improvement and service; the relationship among the electrophysiological homes of neuroglia, mobile cycle, and tumor development; and the various immunological responses and their legislation by means of cellphone cycle.

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Neural Stem Cells 21 85. Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 1999; 19:8487-8497. 86. Gritti A, Frolichsthal-Schoeller P, Galli R, et al. Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain. J Neurosci 1999; 19:3287-3297.

Thus, putative NSCs reside in the adult brain not exclusively in the neurogenic areas in the adult brain, but also in nonneurogenic areas where they will remain quiescent. However, the criteria used to characterize self-renewing, multipotent NSCs, although are well accepted to show that a single cell is a NSC in vitro, are not absolute. The main criticism resides in the number of subcloning steps that one must show to qualify a cell as self-renewing in vitro (84). Recent reports have challenged the isolation and characterization of self-renewing, multipotent NSCs from the adult DG, claiming the DG contains restricted progenitors, highlighting the limitation of in vitro studies to identify putative NSCs, but also differences in isolation procedures (98,99).

44. Imura T, Kornblum HI, Sofroniew MV. The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J Neurosci 2003;23:2824-2832. 45. Zhuo L, Theis M, Alvarez-Maya I, Brenner M, Willecke K, Messing A. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 2001;31:85-94. 46. Barres BA. What is a glial cell. Glia 2003;43:4,5. 47. Goldman S. Glia as neural progenitor cells. Trends Neurosci 2003;26:590-596.

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